Dr. Clark was born and raised in southwestern Michigan. After pursuing undergraduate studies in chemistry, mathematics and Russian at Deep Springs College and Ohio University, he went on to do graduate work in biochemistry, statistics and biometry at Cornell University, receiving his PhD at the end of 1981.
After spending two years of post-doctoral work at Brookhaven National Labs, he moved to
St. Louis to work at Monsanto
Agricultural Co. on molecular design, physiology,
screening, and SAR-guided pesticide synthesis. Tripos lured him away in 1994 to
put his experience to work in expanding the range of
software available to help others working in similar
areas. Bob eventually became Vice President of
Science and Research at Tripos,
which he left to found his own research and consulting
company, Biochemical Infometrics. He was hired as
Director of Life Sciences at Simulations
Plus in January 2010, and became Sr. Research
Fellow in 2018.
He has held an adjunct professorship in the School of
Informatics at Indiana
University since 2006.
The broad range of technical journals for which he
reviews manuscripts - the Journal of Medicinal Chemistry, the Journal of Agricultural
and Food Chemistry, the Journal of Chemical
Information and Modeling, the Journal of Computer-Aided
Molecular Design, the Journal of Computational Chemistry and
Journal of Chemistry, among others - attests to
the breadth of his skill base and experience.
Director of Life Sciences; Sr. Research Fellow.
Notable personal accomplishments include the discovery that beta binomial and gamma distributions can be used to estimate uncertainties for individual predictions derived from ensemble classification and regression QSAR models, respectively. Oversaw the merger of ADMET Predictor and MedChem Studio into a single product with a unified code base. Led research teams devoted to the R&D behind GastroPlus and MembranePlus as well MedChem Studio and ADMET Predictor when they were individual products.
Founder and Chief Scientist.
Research and consulting company launched in mid-2008 to encourage the development, characterization and careful application of molecular design methods.
Adjunct Professor in the School of Informatics.
Sr. Scientist; Director of Research; VP of Science & Research.
Developed isotropic field orientation for CoMFA clustering (IFO-COMFA) and ensemble modelling for HQSAR. Invented the optimizable K-dissimilarity selection method (OptiSim) used in subset selection, fingerprint visualization (HTS DataMiner), combinatorial docking (OptiDock), combinatorial library design (OptDesign), and other Tripos tools. Co-inventor of topomers and CHEMSPACE. Invented the GALAHAD technology used for ligand alignment and pharmacophore elucidation.
Research Specialist; Research Chemist; Herbicide Early Evaluation Team Leader; Sr. Research Chemist.
Elucidated mode(s)-of-action of herbicides by carrying out complementary biochemical and physiological studies of herbicide mode-of-action and metabolism, directing synthetic efforts towards increased potency and selectivity.
Delineated the role of the peroxide burst in soybean resistance to Phytophthora zoospores and its involvement in wheat "resistance" to transformation by Agrobacterium. Helped develop the dot-blot assay for neomycin phosphotransferase (NPT II) now widely used to assess plant transformation.
Responsible for test design and evaluation in primary and secondary greenhouse testing, interfacing with Discovery, Synthesis and Advanced Biology teams. Integrated modelling and experimental design into primary and secondary herbicide evaluations.
Initiated combinatorial synthesis program for fungicide lead follow-up after having created two new herbicide classes, including the company's first chiral field candidate. Responsible for design and synthesis of new herbicides for use in European small grains, and for successfully improving toxicological and environmental profiles by application of biorational principles.
Worked as a post-doctoral student in Geoffrey Hinds laboratory to isolate and characterize cytochrome b6f complex from spinach and to study its interaction with the light harvesting chlorophyll ab binding protein kinase (LHCK) in spinach. This work is still relevant to research being carried on 20 years later (Mullineaux & Emlyn-Jones, J. Exp. Biol. 2005, 56, 389-393).
Doctoral Thesis (1981): "Energy Transduction in Halobacterium halobium." Studied under Russell MacDonald. Demonstrated light-driven ATP synthesis coupled to halorhodopsin turnover both in vivo and in vitro. The latter involved isolating membrane vesicles from mutant cells, loading them with ADP and phosphate by osmotic shock, then measuring light-induced synthesis of ATP inside the vesicles. Minored in statistics and biometry.
Studied the kinetics of NADH:NADP transhydrogenase in submitochondrial particles from bovine heart via UV/VIS spectroscopy using an array of spectrally distinct substrate analogs.